T-cell immune response in initiation, progression, and destabilization of atherosclerosis: a review

T-cell immune response in initiation, progression, and destabilization of atherosclerosis: a review

Blog Article

A detailed characterization of the diversity, clonality, and antigen specificity of the T-cell repertoire contributes to the understanding of the adaptive immune response role in a wide range of diseases, including arteriosclerosis.This article discusses the differentiation of T-lymphocytes and the factors leading to switch assembly their activation in atherosclerosis.Furthermore, the article discusses the data obtained during the analysis of T-cell repertoires in carotid and coronary artery atherosclerosis using new sequencing technologies, such as single-cell sequencing.The importance and peculiarity of studying the diversity of T-lymphocyte subphenotypes, their antigenic specificity, and their interaction with other cells in atherosclerosis are emphasized.The aim of this review was to synthesize data from studies examining the T-cell immune response in atherosclerosis, utilizing T-cell receptor sequencing techniques, Shears including those based on single-cell sequencing technology.